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Moreover, coordinated regulation of ACSL4, LPCAT3, GPX4, and membrane phospholipid remodeling has come to light as a major molecular axis that regulates ferroptosis commitment in a broad range of pathological conditions, including neurodegenerative diseases (Ma et al., 2026)

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Related studies have proved that the mechanisms of ferroptosis mainly include iron-mediated metabolism disorder and amino acid antioxidant system imbalance (Li et al., 2022)